Biodegradation of Deoxynivalenol by Nocardioides sp. ZHH-013: 3-keto-Deoxynivalenol and 3-epi-Deoxynivalenol as Intermediate Products

Biodegradation of Deoxynivalenol by Nocardioides sp. ZHH-013: 3-keto-Deoxynivalenol and 3-epi-Deoxynivalenol as Intermediate Products

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Deoxynivalenol (DON) is one of the most devastating and notorious contaminants in food and animal feed worldwide.A novel DON-degrading strain, Nocardioides sp.ZHH-013, which exhibited complete mineralization of DON, was isolated from soil samples.

The intermediate products of DON generated by this strain were identified read more by high-performance liquid chromatography and ultra-performance liquid chromatography tandem mass spectrometry analyses.It was shown that, on an experimental level, 3-keto-DON was a necessary intermediate product during the conversion from DON to 3-epi-DON.Furthermore, the ZHH-013 strain could also utilize 3-epi-DON.

This DON degradation pathway is a safety concern for food and feed.The mechanism of DON and 3-epi-DON elimination will be further studied, so that new enzymes glitter foam vellen action for DON degradation can be identified.